Anti-CD89 Rabbit Monoclonal Antibody for Flow Cytometry - P24071

Core Product Specifications and Parameters

Biological Background: CD89 Function and Localization

• CD89, also known as Fc alpha receptor (FcalphaR), is encoded by the FCAR gene and belongs to the immunoglobulin superfamily.
• It binds specifically to the Fc region of IgA antibodies, mediating immune effector functions such as cytokine production.
• The receptor is expressed as multiple isoforms (A.1, A.2, A.3) through alternative splicing, with differential expression between blood and mucosal myeloid cells.
• CD89 localizes primarily to the cell membrane, but can also exist in secreted forms.
• It is expressed on monocytes, alveolar macrophages, and other myeloid cells, playing a key role in mucosal immunity.
• Post-translational modifications include glycosylation and disulfide bond formation, which are important for receptor stability and function.

Experimental Guidance and Technical Tips

• The immunogen corresponds to the extracellular domain of CD89, which may contribute to specificity in detecting surface-expressed receptor.
• For flow cytometry, consider titrating the antibody to determine optimal staining concentration.
• Validate reactivity in your sample system, as expression may vary between blood and mucosal myeloid cells.
• Note that CD89 can be shed as a secreted form, so design experiments accordingly.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers and research institutions with reliable access to high-quality IVD raw materials, including validated antibody pairs and monoclonal antibodies like this anti-CD89 clone. Supporting immunological and mucosal research, CamelBio streamlines procurement from concept to clinic with bulk reagents and rare-target sourcing. Enhance your assay development with a seamless supply partner.