Anti-CD71 Monoclonal Antibody () for Flow Cytometry - P02786

Core Product Specifications and Parameters

Biological Background: CD71 Function and Localization

• CD71, also known as transferrin receptor protein 1 (TfR1), is encoded by the TFRC gene and mediates cellular iron uptake via receptor-mediated endocytosis of transferrin-bound iron. Related references: PMID:26214738, PMID:41772062
• It is essential for erythrocyte and nervous system development (by similarity).
• CD71 positively regulates T and B cell proliferation through iron uptake. Related references: PMID:26642240
• The receptor acts as a lipid sensor, modulating mitochondrial fusion via stearoylation-dependent JNK pathway activation and MFN2 degradation. Related references: PMID:26214738
• CD71 serves as a host cell receptor for various pathogens, including new-world arenaviruses, rabies virus, coronaviruses (SARS-CoV, MERS-CoV, SARS-CoV-2), and Plasmodium vivax.
• Subcellularly, CD71 localizes to the cell membrane, melanosomes, and is also secreted.
• Key structural features include a single-pass transmembrane domain, disulfide bonds, glycosylation, palmitoylation, and phosphorylation sites.

Experimental Guidance and Technical Tips

• The immunogen corresponds to amino acids 100-250 of human CD71, likely recognizing an extracellular epitope suitable for flow cytometry.
• Titrate the antibody to determine the optimal staining concentration for your specific cell type and experimental conditions.
• Include appropriate isotype and compensation controls to ensure specificity and accurate data interpretation.
• Validate antibody performance in relevant human cell lines expressing CD71, such as activated T cells, B cells, or erythroid progenitor cells.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio is your dedicated one-stop partner for high-quality IVD raw materials, offering validated antibody pairs, optimized monoclonal antibodies, bulk ancillary reagents, and specialized sourcing for rare targets like CD71. Whether you need this -conjugated anti-CD71 antibody for diagnostic flow cytometry assays or require custom raw material solutions for iron metabolism and infectious disease research, CamelBio bridges the gap from concept to clinic with reliable supply and expert support.