Anti-CD6 Rabbit Polyclonal Antibody for WB & ELISA - P30203

Core Product Specifications and Parameters

Biological Background: CD6 Function and Localization

• Mediates cell-cell contacts and regulates T-cell responses via interaction with ALCAM/CD166. Related references: PMID:15048703, PMID:15294938, PMID:16352806
• Functions as a costimulatory molecule, promoting T-cell activation and proliferation, and contributes to the formation and maturation of the immunological synapse. Related references: PMID:15294938, PMID:16352806, PMID:16914752
• Contributes to signaling cascades triggered by activation of the TCR/CD3 complex. Related references: PMID:24584089
• Functions as a calcium-dependent pattern receptor, binding both Gram-positive and Gram-negative bacteria, and mediates inflammatory responses via LPS-induced MAP kinase activation. Related references: PMID:17601777
• Localizes to the cell membrane and is also found as a soluble secreted form.
• Detected on thymocytes, peripheral blood T-cells, natural killer cells, and a subset of B-cells; soluble CD6 is present in blood serum. Related references: PMID:15048703, PMID:15294938, PMID:16352806, PMID:17601777, PMID:9013954
• Undergoes post-translational modifications including glycosylation and phosphorylation, and contains disulfide bonds; alternative splicing produces multiple isoforms.

Experimental Guidance and Technical Tips

• The immunogen corresponds to the intracellular region (aa 424–668), making the antibody well-suited for detecting total CD6 in denaturing Western blot assays.
• For ELISA, consider using recombinant CD6 protein or human cell lysates as the coating antigen; optimization of blocking and detection conditions is recommended.
• Since cross-reactivity is limited to human CD6, validate the antibody in the relevant human sample system and confirm species specificity if used with other species.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers, labs, and research institutes with one-stop access to IVD raw materials, technical services, and consulting—covering every stage from concept to clinic. This anti-CD6 rabbit polyclonal antibody is part of CamelBio's extensive catalog of immune target antibodies, supporting T-cell biology and immunology research. Whether you need validated antibody pairs, bulk ancillary reagents, or rare target raw-material sourcing, CamelBio streamlines your procurement with a single touchpoint.