Anti-CD55 Monoclonal Antibody () for Flow Cytometry - P08174

Core Product Specifications and Parameters

Biological Background: CD55 (Decay-Accelerating Factor) Function and Localization

• CD55 binds to C4b and C3b fragments, interfering with the formation and stability of C3 and C5 convertases, thereby protecting cells from autologous complement attack.
  Related references:
  PMID:7525274 PMID:28657829
• CD55 serves as a receptor for several viruses, including Coxsackievirus A21, coxsackieviruses B1/B3/B5, human enterovirus 70 and D68, and echoviruses 6/7/11/12/20/21.
• The protein is primarily anchored to the cell membrane via a GPI linkage, but soluble forms are also found in body fluids and the extracellular matrix.
• CD55 is broadly expressed on the plasma membranes of cells exposed to plasma complement proteins, as well as on epithelial cells lining extracellular compartments.
• The mature protein contains multiple Sushi (CCP) domains, is heavily glycosylated, and stabilized by disulfide bonds.
• CD55 is the carrier of the Cromer blood group system and is associated with complement-mediated disorders, including CHAPLE syndrome.

Experimental Guidance and Technical Tips

• The immunogen covers the extracellular domain (aa 35-353) of human CD55, targeting regions essential for ligand binding; this design favors recognition of native, membrane‑bound CD55 in flow cytometry.
• This antibody is validated for flow cytometry; for other applications such as IHC or western blot, thorough validation in the relevant sample system is recommended.
• The conjugate offers bright, photostable fluorescence; avoid repeated freeze‑thaw cycles and protect from light to maintain optimal performance.

CamelBio: Your One-Stop Sourcing Bridge

This anti-CD55 monoclonal antibody supports research into complement regulation and viral pathogenesis, and is available through CamelBio’s comprehensive IVD raw‑material supply network. In addition to mono‑specific reagents like this one, we offer validated antibody pairs, customized bulk antibodies, and ancillary reagents—all backed by technical consulting services. Whether you need a single critical reagent or a complete kit component, CamelBio is your partner in moving diagnostics from concept to clinic.