Anti-CD38 Monoclonal Antibody for Flow Cytometry - P28907

Core Product Specifications and Parameters

Biological Background: CD38 Function and Localization

• CD38, also known as ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1, is a multifunctional transmembrane glycoprotein that belongs to the ADP-ribosyl cyclase family.
• It enzymatically synthesizes cyclic ADP-ribose (cADPR), a second messenger involved in glucose-induced insulin secretion, and also has cADPR hydrolase activity. Related references: PMID:7961800, PMID:8253715
• CD38 converts NADP+ to nicotinate-adenine dinucleotide phosphate (NAADP+), a potent Ca2+ mobilizer, with substrate preference depending on pH. Related references: PMID:16690024
• As a receptor, CD38 binds to CD31 on endothelial cells, promoting lymphocyte activation, proliferation, and transendothelial migration. Related references: PMID:9551996
• In dendritic cells, CD38 regulates maturation-dependent functions including CCL21-driven migration, survival, and Th1 polarization. Related references: PMID:16293598
• In lamina propria T lymphocytes, CD38/CD31 engagement triggers LCK and LAT activation, leading to cytokine release. Related references: PMID:11259373
• CD38 is localized to the cell surface membrane and is expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma, and neuroblastoma.
• The protein undergoes alternative splicing, producing isoforms with approximate molecular weights of 13 kDa and 34 kDa (UniProt: P28907).

Experimental Guidance and Technical Tips

• The immunogen corresponds to amino acids 43–300 of human CD38, covering a large extracellular region; this design may help detect both soluble and membrane-bound forms.
• This product is validated for flow cytometry (FC). For other applications, consider titration and sample-specific optimization.
• Given CD38 expression in multiple tissues, include appropriate positive and negative controls (e.g., lymphoma cell lines) in FC experiments.
• Store the antibody as recommended (ice bag shipping) to maintain conjugate stability; protect from light during handling.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio is your one-stop sourcing partner for IVD raw materials, offering validated antibody pairs, optimized monoclonal/polyclonal antibodies, and bulk ancillary reagents. For CD38-related research in immunology, diabetes, and oncology, CamelBio can assist with sourcing antibodies for flow cytometry, ELISA, and other immunoassays, complemented by technical services from concept to clinic. We also support rare-target raw-material procurement to accelerate your diagnostic development.