Anti-CD353/SLAMF8 Monoclonal Antibody for Flow Cytometry - Q9P0V8

Core Product Specifications and Parameters

Biological Background: CD353/SLAMF8 Function and Localization

• SLAMF8 (also known as BLAME, CD353, SBBI42) is a member of the signaling lymphocytic activation molecule (SLAM) family, characterized by an extracellular immunoglobulin domain and involvement in immune cell regulation.
• It may play a role in B-lineage commitment and/or modulation of signaling through the B-cell receptor.
• The protein is localized to the cell membrane, consistent with its function as a receptor.
• SLAMF8 is predominantly expressed in lymphoid tissues, including lymph node, spleen, thymus, and bone marrow.
• Structurally, SLAMF8 is a glycoprotein with predicted disulfide bonds and a single transmembrane helix.
• Alternative splicing of the SLAMF8 gene generates multiple isoforms, which may have distinct functional properties.

Experimental Guidance and Technical Tips

• For flow cytometry, the directly conjugated dye allows single-step staining. Use appropriate isotype control antibodies to assess non-specific binding.
• The immunogen corresponds to the extracellular domain (residues 23–123), suggesting the antibody targets an external epitope accessible in live-cell staining.
• Since SLAMF8 expression is reported in lymphoid tissues, consider using human peripheral blood mononuclear cells (PBMCs) or B-cell lines for validation.
• Ensure proper sample handling and temperature conditions during staining and acquisition to maintain fluorescence stability.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio is your dedicated partner for sourcing high-quality IVD raw materials, including validated monoclonal antibodies like this anti-CD353/SLAMF8 reagent for immune-oncology and B-cell research. We provide a comprehensive portfolio of bulk reagents, antibody pairs, and custom development services to accelerate your diagnostic assay pipeline.