Anti-CD352/SLAMF6 Monoclonal Antibody for FC - Q96DU3

Core Product Specifications and Parameters

Biological Background: CD352/SLAMF6 Function and Localization

• SLAMF6 (CD352) is a self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family, modulating activation and differentiation of various immune cells including T, B, and natural killer (NK) cells. Related references: PMID:11489943 PMID:16920955
• Triggers cytolytic activity in NK cells expressing high densities of natural cytotoxicity receptors, with signaling involving VAV1 phosphorylation and dependence on the adaptor SH2D1B. Related references: PMID:16920955
• Promotes T-cell differentiation into a Th17 phenotype, enhancing IL-17 secretion via recruitment of RORC to the IL-17 promoter; this co-stimulatory activity requires SH2D1A. Related references: PMID:22184727 PMID:22989874
• Negatively regulates the humoral immune response by inhibiting germinal center formation through reduced T-cell:B-cell adhesion, associated with increased PTPN6/SHP-1 recruitment in the absence of SH2D1A.
• Subcellular localization is at the cell membrane, consistent with its role as a transmembrane receptor.
• Expressed by resting and activated NK, T, and B lymphocytes; surface expression is elevated on T-cells from systemic lupus erythematosus (SLE) patients. Related references: PMID:22184727
• Contains key post-translational modifications: glycosylation, phosphorylation, and disulfide bonds, with alternative splicing reported.
• Belongs to the immunoglobulin superfamily and is involved in both innate and adaptive immunity.

Experimental Guidance and Technical Tips

• The immunogen encompasses the extracellular domain (aa 24-215), making this antibody suitable for detecting surface CD352/SLAMF6 via flow cytometry on live cells.
• When setting up FC assays, consider titrating the antibody to determine the optimal staining concentration for your specific cell type (e.g., human PBMCs or isolated lymphocyte subsets).
• Validate the antibody's performance in your relevant sample system, particularly if using primary cells from disease states (e.g., SLE) where expression may be modulated.
• Ensure appropriate compensation controls are used due to the conjugate to minimize spectral overlap in multicolor panels.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio serves as a comprehensive procurement partner for diagnostic manufacturers, laboratories, and research institutes, offering ready-to-use monoclonal antibodies, validated antibody pairs, and ancillary reagents. This anti-CD352/SLAMF6 antibody supports immune cell phenotyping and functional studies, complementing our portfolio of immune checkpoint and SLAM family targets. Whether you require bulk quantities, customized conjugations, or assistance with rare-target reagent sourcing, our team is equipped to accelerate your project from concept to clinic.