Anti-CD351/FCAMR Monoclonal Antibody for ELISA, IF/ICC, FC - Q8WWV6

Core Product Specifications and Parameters

Biological Background: CD351/FCAMR Function and Localization

• CD351, also known as Fc alpha/mu receptor (FCAMR), is a high affinity receptor for the Fc fragment of immunoglobulin A (IgA) and immunoglobulin M (IgM).
• It mediates endocytosis of IgA and IgM immune complexes, playing a role in adaptive immunity and the immune response to microbes.
• The receptor is a single-pass type I transmembrane protein localized to the cell membrane.
• FCAMR expression is detected in mesangial cells, indicating tissue-specific functions in the kidney.
• The protein contains an immunoglobulin-like domain, a signal peptide, and a transmembrane helix; it is subject to disulfide bond formation and glycosylation.
• Alternative splicing generates multiple isoforms with predicted molecular weights of approximately 24 kDa, 46 kDa, and 57 kDa.
• KEYWORDS: Adaptive immunity, Alternative splicing, Cell membrane, Disulfide bond, Glycoprotein, Immunity, Immunoglobulin domain, Membrane, Receptor, Signal, Transmembrane.

Experimental Guidance and Technical Tips

• The immunogen corresponds to the extracellular domain (amino acids 17-450) of the human CD351/FCAMR isoform 1, making this antibody suitable for detecting the receptor in native cell surface conformation via IF/ICC and flow cytometry (FC).
• For ELISA applications, consider using recombinant CD351/FCAMR protein as the coating antigen and validate assay conditions with positive and negative control samples.
• This antibody is validated for human targets; cross-reactivity with other species should be independently tested if used in non-human systems.
• Given the presence of multiple isoforms, confirm the detected band(s) in Western blot if applicable; however, Western blot is not listed as a recommended application.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio is your dedicated one-stop partner for IVD raw material supply, bridging the gap from concept to clinical application. For CD351/FCAMR-related diagnostic and research projects, we offer validated antibody pairs, optimized monoclonal antibodies, bulk ancillary reagents, and rare target sourcing to streamline your assay development.