Anti-CD200 Rabbit Monoclonal Antibody for WB, IHC-P, ELISA - P41217

Core Product Specifications and Parameters

Biological Background: CD200 Function and Localization

• OX-2 membrane glycoprotein (CD200) is a cell surface glycoprotein encoded by the CD200 gene, also known as MOX1, MOX2, MRC, and OX-2.
• It functions as a costimulator of T-cell proliferation, enhancing immune responses.
• CD200 may regulate myeloid cell activity across various tissues, contributing to immune homeostasis.
• The protein is localized at the cell membrane, consistent with its role in cell-cell interactions.
• Keywords: Alternative splicing generates multiple isoforms; contains an immunoglobulin domain; is heavily glycosylated; and features a signal peptide and a transmembrane helix.

Experimental Guidance and Technical Tips

• The immunogen spans amino acids 31-232 of the extracellular region, which may ensure recognition of both glycosylated and unglycosylated forms.
• WB: Consider using reducing conditions and a ~31 kDa band; validate in relevant human, mouse, or rat tissue lysates.
• IHC-P: Antigen retrieval may be required; optimize for paraffin-embedded sections.
• ELISA: Suitable for antigen capture or detection; pair with appropriate secondary reagents.

CamelBio: Your One-Stop Sourcing Bridge

As a dedicated IVD raw-material partner, CamelBio provides diagnostic manufacturers and research institutes with a reliable supply of high-quality antibodies like this CD200 monoclonal antibody, supporting immunology and oncology assay development. Our portfolio includes validated antibody pairs, bulk ancillary reagents, and customized sourcing services for rare targets, streamlining your transition from concept to clinic.