Anti-CD2 Rabbit PolymAb® Monoclonal Antibody for WB, IHC-P, ELISA - P06729/P08920

Core Product Specifications and Parameters

Biological Background: CD2 Function and Localization

• CD2, also known as T11, SRBC, or LFA-2, is a T-cell surface antigen and a member of the immunoglobulin superfamily, functioning as a receptor for LFA-3 (CD58) and CD48/BCM1.
• It mediates adhesion between T cells and antigen-presenting cells or target cells, playing a crucial role in T-cell activation and immune response.
• The cytoplasmic domain of CD2 is involved in signal transduction, contributing to T-cell triggering.
• CD2 is localized to the cell membrane as a single-pass type I membrane protein.
• It is expressed not only on T cells but also on natural killer cells, as detected at the protein level.
• Post-translational modifications include glycosylation and disulfide bond formation, which are important for its structure and function.
• The human CD2 has a predicted molecular weight of approximately 39.4 kDa, while the mouse ortholog (P08920) is about 39 kDa; detected at 38-39 kDa by Western blot.

Experimental Guidance and Technical Tips

• For Western blot, human and mouse CD2 migrates at 38-39 kDa; consider using positive controls like Jurkat cells (human) or EL4 cells (mouse).
• For immunohistochemistry (IHC-P), antigen retrieval may be required; validate in lymphoid tissues where CD2 is expressed.
• This antibody is produced in rabbit as a PolymAb® (recombinant monoclonal), ensuring high consistency and specificity.
• Cross-reactivity with human and mouse ensures utility in multi-species studies; verify expected band size in your sample system.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio supports diagnostic manufacturers, laboratories, and research institutes with integrated access to IVD raw materials and technical services. Our CD2 antibody is part of a comprehensive portfolio for immunology and immune-oncology applications, including validated antibody pairs, optimized recombinant monoclonals, and ancillary reagents. Whether you need bulk quantities or rare-target sourcing, CamelBio bridges your concept to clinic.