Anti-CD163L1 Rabbit Polyclonal Antibody for WB, ELISA - Q9NR16

Core Product Specifications and Parameters

Biological Background: CD163L1 Function and Localization

• CD163L1, designated as M160 or CD163B, is a scavenger receptor cysteine-rich type 1 protein.
• The CD163L1 gene produces at least two isoforms (isoform 1 and isoform 2) through alternative splicing.
• The protein features SRCR repeats, a transmembrane segment, and a signal peptide, and is annotated as both a membrane and secreted protein.
• Isoform 1 is a membrane glycoprotein predominantly expressed in spleen, lymph nodes, thymus, and fetal liver, restricted to monocyte/macrophage cells; isoform 2 is a secreted protein only detected in spleen.
• It undergoes disulfide bond formation and glycosylation, as indicated by its UniProt keywords.
• The protein has a molecular weight of approximately 159 kDa.

Experimental Guidance and Technical Tips

• The immunogen corresponds to amino acids 350–550 of human CD163L1, a region likely spanning part of the extracellular SRCR domains. Consider verifying epitope accessibility in your specific assay setup.
• This antibody is validated for western blot (WB) and ELISA. For WB, consider using a suitable loading control and validate specificity using appropriate cell or tissue lysates known to express CD163L1 (e.g., human spleen or macrophage-like cells).
• Cross-reactivity with rat has been observed. For rodent studies, confirm reactivity in your system.
• The predicted molecular weight is ~159 kDa; ensure your gel percentage allows resolution of high-molecular-weight proteins.
• Because the protein may be glycosylated, the observed band might shift; deglycosylation could be used to verify target specificity.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio is your trusted one-stop partner for IVD raw materials, offering a comprehensive portfolio including validated polyclonal and monoclonal antibodies, antibody pairs, and ancillary reagents for diagnostic development. This CD163L1 antibody supports immunodetection research in macrophage biology and immune function. For your specialized needs—from rare target sourcing to bulk supply—CamelBio provides end-to-end support to accelerate your project from concept to clinic.