Anti-CD138/Syndecan-1 Rabbit Monoclonal Antibody for IHC-P, ELISA - P18827

Core Product Specifications and Parameters

Biological Background: CD138/Syndecan-1 Function and Localization

• Syndecan-1 (CD138/SDC/SYND1) is a transmembrane heparan sulfate proteoglycan that also carries chondroitin sulfate chains.
• It acts as a linker between the cytoskeleton and the interstitial matrix (by similarity).
• It regulates exosome biogenesis by cooperating with SDCBP and PDCD6IP (PubMed:22660413). Related references: PMID:22660413
• It can induce its own expression in dental mesenchymal and epithelial cells through an MSX1-mediated pathway (by similarity).
• Subcellularly, it is located at the plasma membrane and is also secreted into the extracellular exosome.
• It is expressed in placenta and fibroblasts at the protein level (PubMed:32337544; PubMed:36213313). Related references: PMID:32337544 / PMID:36213313
• Post-translational modifications include phosphorylation and glycosylation, including attachment of heparan sulfate chains (by similarity).

Experimental Guidance and Technical Tips

• The recombinant protein immunogen covers a region of human Syndecan-1; confirm epitope specificity for your intended use.
• This rabbit monoclonal antibody is reported for IHC-P; verify performance on your specific tissue types and fixation protocols.
• For ELISA applications, optimize coating and detection conditions; the antibody may recognize both membrane-bound and soluble forms.
• Consider cross-reactivity with other syndecan family members; validation with relevant controls is advised.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio is your one-stop partner for IVD raw material sourcing, offering validated antibody pairs, monoclonal/polyclonal antibodies, bulk ancillary reagents, and custom procurement for rare targets. Our supply chain expertise supports diagnostic manufacturers and researchers in oncology, immunology, and infectious disease areas, including CD138/Syndecan-1-related studies. Contact us to discuss your specific assay development needs.