Anti-CD105/Endoglin Rabbit Polyclonal Antibody for WB and ELISA - P17813

Core Product Specifications and Parameters

Biological Background: Endoglin Function and Localization

• Endoglin is a transmembrane glycoprotein and member of the zona pellucida (ZP) domain-containing protein family, encoded by the ENG gene; alternative splicing produces multiple isoforms.
• Endoglin is a key regulator of angiogenesis, required for endothelial cell migration and normal vascular structure and integrity. Related references: PMID:21737454, PMID:23300529, PMID:17540773, PMID:7894484
• Endoglin serves as a TGF-beta superfamily co-receptor, modulating both BMP9 and TGF-beta1 signaling to activate SMAD1 and SMAD3 transcription factors. Related references: PMID:21737454, PMID:22347366, PMID:23300529
• It is localized to the cell membrane and mediates endothelial cell adhesion by binding integrins and RGD-containing proteins. Related references: PMID:1692830
• Post-translational modifications include disulfide bonds, N-linked glycosylation, and phosphorylation, which may regulate its function.
• Endoglin is highly expressed in vascular endothelial cells and placenta. Related references: PMID:10625079, PMID:1692830
• Mutations in ENG cause hereditary hemorrhagic telangiectasia type 1 (HHT1/ORW1), underscoring its vascular importance.

Experimental Guidance and Technical Tips

• The immunogen corresponds to the N-terminal extracellular domain (aa 26-337), which is predicted to be exposed on the cell surface; this design may enhance recognition of native Endoglin in ELISA and denatured forms in WB.
• For WB, the predicted molecular weight is approximately 71 kDa; glycosylated forms may migrate slightly higher.
• Cross-reactivity with mouse is reported; consider performing sequence alignment to assess suitability for other species.
• As a polyclonal antibody, it may exhibit lot-to-lot variability; validate performance in your specific sample system.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio supports your vascular biology and angiogenesis research with this anti-Endoglin antibody and a comprehensive range of IVD raw-material solutions. Our portfolio includes validated antibody pairs, optimized polyclonal antibodies, bulk ancillary reagents, and rare target sourcing—helping diagnostic manufacturers and labs streamline development from concept to clinic.