Anti-CD102 Rabbit Polyclonal Antibody for WB, ELISA - P35330

Core Product Specifications and Parameters

Biological Background: CD102 Function and Localization

• CD102 (ICAM-2) is a cell adhesion molecule that serves as a ligand for LFA-1 (ITGAL:ITGB2), facilitating leukocyte adhesion on resting cells. Related references: PMID:1401904
• It also acts as a receptor for dendritic cell-specific ICAM-3-grabbing non-integrin (DC-SIGN/CD209) on endothelial cells, mediating transendothelial migration of dendritic cell precursors.
• The protein is a member of the immunoglobulin superfamily and contains multiple immunoglobulin-like domains, a transmembrane region, and a cytoplasmic tail.
• CD102 localizes to the cell membrane and is enriched in microvillus-like projections on the cell surface.
• It is expressed predominantly in endothelial cells and leukocytes, with high levels detected in the lung.
• Post-translational modifications include N-linked glycosylation and disulfide bond formation, which are critical for its structural integrity and function.
• Keywords: 3D-structure, Cell adhesion, Cell membrane, Cell projection, Disulfide bond, Glycoprotein, Immunoglobulin domain, Membrane, Reference proteome, Repeat, Signal, Transmembrane, Transmembrane helix.

Experimental Guidance and Technical Tips

• This polyclonal antibody was raised against the extracellular domain of mouse CD102 (amino acids 20-222), making it suitable for detecting the native protein in cell-surface applications.
• For Western blot, expect a band at approximately 31 kDa; consider using a reducing agent to ensure complete denaturation.
• The antibody cross-reacts with rat CD102; validate specificity in the relevant sample system to confirm reactivity.
• For ELISA, the recombinant protein used as immunogen can serve as a positive control; optimize coating and detection conditions accordingly.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers, labs, and research institutes with one-stop access to IVD raw materials, technical services, and consulting—covering every stage from concept to clinic. This anti-CD102 antibody supports immunology and cell adhesion research, and we can also supply validated antibody pairs, optimized monoclonal/polyclonal antibodies, bulk ancillary reagents, and rare target raw-material sourcing. Contact us to explore how we can accelerate your project's development.