Anti-CCR9 Rabbit Polyclonal Antibody for WB, ELISA - P51686

Core Product Specifications and Parameters

Biological Background: CCR9 Function and Localization

• C-C chemokine receptor type 9 (CCR9), also known as GPR28 or GPR-9-6, is a member of the G protein-coupled receptor family. Alternative splicing produces multiple transcript variants.
• Serves as a receptor for the chemokine CCL25 (SCYA25/TECK), and upon ligand binding, transduces signals by increasing intracellular calcium ion levels, mediating immune cell migration.
• CCR9 plays a role in HIV-1 infection as an alternative coreceptor with CD4 for viral entry.
• Localizes to the cell membrane as a multi-pass transmembrane protein.
• Contains structural features typical of chemokine receptors, including disulfide bonds and glycosylation sites.
• Highly expressed in the thymus, with lower expression observed in lymph nodes and spleen.
• Participates in host-virus interactions, highlighting its significance in both immunology and infectious disease.

Experimental Guidance and Technical Tips

• The immunogen is a synthetic peptide corresponding to amino acids 300-369, located in the C-terminal region. This region may be suitable for detection of both full-length and some truncated isoforms.
• For Western blotting, a band around 42 kDa is expected under reducing conditions. Verify with the relevant sample system and optimize loading controls.
• For ELISA, consider both direct and indirect assay formats. Validate the antibody’s performance in your specific sample matrix to ensure specificity.
• Cross-reactivity is reported with human, mouse, and rat. When working with other species, confirm homology in the target region and validate accordingly.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio serves as a one-stop sourcing partner for IVD raw materials, supporting diagnostic manufacturers and researchers. Our CCR9 antibody portfolio addresses immunology and infectious disease targets, with validated polyclonal and monoclonal options. We provide consistent bulk supply, antibody pairs, and rare-target sourcing to accelerate your assay development.