Anti-CCM2 Rabbit Polyclonal Antibody for WB, IHC-P, ELISA - Q9BSQ5

Core Product Specifications and Parameters

Biological Background: CCM2 Function and Localization

• CCM2 encodes the cerebral cavernous malformations 2 protein, also known as malcavernin, which undergoes alternative splicing to generate multiple isoforms.
• As a core component of the CCM signaling pathway, CCM2 plays a critical role in regulating heart and blood vessel formation and maintaining endothelial integrity.
• It is thought to act as a scaffold protein, facilitating MAP2K3-MAP3K3 signal transduction and modulating p38 MAPK activation in response to hyperosmotic stress.
• CCM2 localizes predominantly to the cytoplasm, where it may help stabilize endothelial cell junctions.
• The protein is subject to phosphorylation, suggesting regulation by kinase-mediated signaling pathways.
• Mutations in CCM2 are linked to cerebral cavernous malformations, a vascular disorder, highlighting its essential role in vascular development and homeostasis.

Experimental Guidance and Technical Tips

• The immunogen corresponds to the N-terminal region (aa 1-300) of human CCM2, which may recognize multiple isoforms; validate detection in your sample system.
• For Western blot, expect a band near 49 kDa; however, alternative splicing products or post-translational modifications could yield additional bands.
• The antibody has been reported to cross-react with mouse and rat CCM2 due to sequence conservation, making it suitable for studies across these species.
• In IHC-P, consider optimized antigen retrieval protocols and appropriate controls to confirm specificity.
• For ELISA applications, pair this antibody with matched detection reagents to ensure robust signal.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio is a leading one-stop platform that connects diagnostic manufacturers and research laboratories with high-quality IVD raw materials. As part of our comprehensive portfolio, this anti-CCM2 polyclonal antibody supports studies on cardiovascular development and vascular disorders. Beyond individual antibodies, we offer validated antibody pairs, optimized monoclonal and polyclonal reagents, bulk ancillary supplies, and specialized sourcing for rare-target raw materials—making CamelBio your reliable partner from concept to clinic.