Anti-CCDC6 Polyclonal Antibody for WB, IHC-P, IF/ICC, ELISA - Q16204

Core Product Specifications and Parameters

Biological Background: CCDC6 Function and Localization

• CCDC6 (Coiled-coil domain-containing protein 6) is also known as Papillary thyroid carcinoma-encoded protein, Protein H4, PTC, TPC, TST1, or D10S170.
• It is a cytoplasmic protein that associates with the cytoskeleton, consistent with its subcellular localization.
• CCDC6 is ubiquitously expressed across human tissues.
• The protein contains coiled-coil domains and SH3-binding motifs, suggesting a role in mediating protein-protein interactions.
• CCDC6 is recognized as a proto-oncogene and is frequently involved in chromosomal rearrangements, particularly in papillary thyroid carcinoma.
• Post-translational modifications include acetylation, methylation, and phosphorylation, which may regulate its activity and interactions.
• The canonical function of CCDC6 is not explicitly described in current reference databases.

Experimental Guidance and Technical Tips

• The immunogen corresponds to a central region (aa 55–222) of human CCDC6, raising polyclonal antibodies that recognize multiple epitopes; this design may enhance detection sensitivity across species.
• A prominent band near 53 kDa is expected in Western blot analysis; consider optimizing loading controls and validation with appropriate cell or tissue lysates.
• For immunohistochemistry (IHC-P) and immunofluorescence (IF/ICC), the cytosolic and cytoskeletal localization of CCDC6 warrants careful selection of fixation and permeabilization conditions to preserve antigenicity.
• ELISA can be utilized for quantitative detection or titer determination; always include relevant positive and negative controls to confirm specificity.
• Given the cross-reactivity with mouse and rat, verify antibody performance in your target species and experimental model.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio offers a streamlined supply chain for IVD raw materials, connecting diagnostic manufacturers and researchers with high-quality antibodies and reagents. For studies focused on CCDC6—a proto-oncogene implicated in thyroid carcinoma and cytoskeletal dynamics—we provide validated polyclonal antibodies, antibody pairs, and bulk ancillary reagents. Whether you require optimized monoclonal/polyclonal options or rare target raw-material sourcing, CamelBio is your reliable partner from concept to clinic.