Anti-CCDC124 Polyclonal Antibody for WB, IHC-P, ELISA - Q96CT7

Core Product Specifications and Parameters

Biological Background: CCDC124 Function and Localization

• CCDC124, also known as Lso2 or oxs1, is a coiled-coil domain-containing protein encoded by the CCDC124 gene on human chromosome 19.
• It functions as a ribosome-binding protein that promotes ribosome hibernation by stabilizing the nonrotated conformation of the 80S ribosome, thereby preserving translationally inactive ribosomes. Related references: PMID:32687489
• CCDC124 is required for proper progression of late cytokinetic stages, ensuring successful cell division. Related references: PMID:23894443
• The protein localizes to the cytoplasm, centrosome, and midbody during cell division, consistent with its role in cytokinesis.
• Ubiquitously expressed across tissues.
• Keywords highlight its involvement in cell cycle and cell division, along with structural features like coiled-coil domains and phosphorylation.
• The protein has a molecular weight of approximately 26 kDa (calculated 25.8 kDa).

Experimental Guidance and Technical Tips

• The immunogen used is a recombinant fusion protein corresponding to the full-length human CCDC124 (amino acids 1-223). This should detect endogenous CCDC124 across species with conserved sequence (predicted cross-reactivity with human, mouse, and rat).
• For Western blot, the expected band size is ~26 kDa. Consider using positive control lysates from human, mouse, or rat cell lines known to express CCDC124 (ubiquitously expressed).
• For IHC-P, antigen retrieval conditions may be required; test with appropriate tissue sections where CCDC124 is expressed, such as proliferating cells.
• This polyclonal antibody is suitable for ELISA detection of recombinant or endogenous CCDC124; titrate for optimal signal.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers and research labs with integrated access to high-quality IVD raw materials, from validated antibody pairs to bulk ancillary reagents. For CCDC124 and related cell cycle targets, we source optimized polyclonal antibodies and can support your development of robust immunoassays. Let CamelBio be your partner in accelerating projects from concept to clinic.