Anti-CCDC124 Polyclonal Antibody for WB, IHC-P, ELISA - Q96CT7

Core Product Specifications and Parameters

Biological Background: CCDC124 Function and Localization

• CCDC124 (Coiled-coil domain-containing protein 124), also known as Lso2 or oxs1, is encoded by the CCDC124 gene (GeneID: 115098) in humans.
• Functions as a ribosome-binding protein that associates with translationally inactive 80S ribosomes, stabilizing their nonrotated conformation and promoting ribosome hibernation and storage. Related references: PMID:32687489
• Plays a role in cell division, specifically required for proper progression of late cytokinetic stages. Related references: PMID:23894443
• Localizes to the cytoplasm, and during cell division, to the centrosome and midbody, which are microtubule organizing center structures.
• Ubiquitously expressed across tissues, indicating a fundamental cellular function.
• Contains coiled-coil domains, characteristic of proteins involved in protein-protein interactions.
• Identified as a phosphoprotein and has been characterized by 3D-structure determination (referenced in UniProt keywords).

Experimental Guidance and Technical Tips

• For Western blotting, a band around 26kDa is expected; validate the antibody using appropriate positive and negative controls in the relevant sample system.
• For immunohistochemistry (IHC-P), consider testing with formalin-fixed paraffin-embedded tissues, and optimize antigen retrieval conditions.
• ELISA applications may require determining the optimal coating concentration and detection range; cross-reactivity with mouse and rat suggests suitability for multi-species studies.
• The immunogen corresponds to the full-length human CCDC124 protein, which may result in recognition of multiple epitopes; consider using appropriate blocking and detection conditions to minimize non-specific binding.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio is a one-stop sourcing partner for IVD raw materials, offering validated antibody pairs, optimized polyclonal antibodies like this anti-CCDC124 antibody, bulk ancillary reagents, and rare target raw-material sourcing. Supporting research into ribosome biology and cell division, CamelBio helps diagnostic developers and labs accelerate their projects from concept to clinic.