Anti-CAVIN2 Rabbit Polyclonal Antibody for WB, IHC-P, ELISA - O95810

Core Product Specifications and Parameters

Biological Background: CAVIN2 Function and Localization

• CAVIN2 (Caveolae-associated protein 2), also known as SDPR, PS-p68, or cavin-2, is a phosphatidylserine-binding protein encoded by the CAVIN2 gene; it belongs to the cavin family of caveolar coat proteins.
• Plays a key role in caveolar biogenesis and morphology by inducing membrane curvature within caveolae, a process essential for caveola formation and stability. Related references: PMID:19525939
• Exhibits tissue-specific regulation: required for caveola formation in lung and fat endothelia but not in heart endothelia; negatively modulates the size or stability of CAVIN complexes in lung endothelial cells.
• Subcellular localization includes cytoplasm, cytosol, and membrane caveola, consistent with its dynamic role in caveolar assembly and trafficking.
• Post-translationally modified by acetylation and phosphorylation, which may modulate its function and interactions; identified through proteomics and direct protein sequencing.
• Highly expressed in heart and lung, with lower levels in brain, kidney, liver, pancreas, placenta, and skeletal muscle, reflecting its tissue-specific importance.
• May participate in targeting PRKCA (protein kinase C alpha) to caveolae, linking it to signal transduction pathways (By similarity).

Experimental Guidance and Technical Tips

• The immunogen is a synthetic peptide spanning residues 325–425; consider validating epitope recognition in your specific sample system using peptide competition or fragment controls.
• For Western blot (WB), use whole-cell or tissue lysates from high-expressing sources (heart, lung) with a predicted band around 47 kDa; optimize loading and transfer conditions.
• In immunohistochemistry (IHC-P), antigen retrieval and tissue fixation conditions may influence staining; positive controls such as lung or heart sections are recommended.
• Cross-reactivity is reported for human, mouse, and rat; for other species, check sequence homology of the immunogen region before use.
• ELISA applications should consider the polyclonal nature; include negative control coatings and validate with recombinant CAVIN2 or cell lysates.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides a streamlined one-stop sourcing experience for IVD raw materials, including this anti-CAVIN2 polyclonal antibody for caveolae-related research. Our portfolio supports diagnostic developers with validated antibody pairs, optimized monoclonals/polyclonals, bulk ancillary reagents, and rare-target raw-material sourcing. Partner with CamelBio to bridge your research and production needs efficiently.