Anti-Caveolin-3 Rabbit Monoclonal Antibody for WB, IHC-P, ELISA - P56539

Core Product Specifications and Parameters

Biological Background: Caveolin-3 Function and Localization

• Caveolin-3 is a 17 kDa muscle-specific member of the caveolin family, serving as a scaffolding protein in caveolar membranes.
• It directly interacts with G protein alpha subunits to regulate their activity and modulates voltage-gated potassium channels.
• Critical for sarcolemma repair in skeletal muscle and cardiomyocytes, enabling rapid resealing after mechanical stress (By similarity).
• Mediates recruitment of CAVIN2 and CAVIN3 proteins to caveolae. Related references: PMID:19262564
• Localizes to the Golgi apparatus membrane, cell membrane, caveolae, and sarcolemma.
• Expressed predominantly in muscle.
• Associated with diseases such as cardiomyopathy, limb-girdle muscular dystrophy, and long QT syndrome.

Experimental Guidance and Technical Tips

• The immunogen spans the full-length human Caveolin-3 (aa1-151); for precise epitope mapping, consider using peptide competition assays.
• For Western blot, the predicted molecular weight is ~17 kDa; validate band specificity with knockdown or knockout lysates.
• For IHC-P, antigen retrieval may be required; optimize conditions for your specific tissue type and fixation method.
• Cross-reactivity with mouse and rat suggests suitability for in vivo models; confirm with appropriate tissue controls.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers, labs, and research institutes with one-stop access to IVD raw materials, technical services, and consulting—covering every stage from concept to clinic. Our expert team supports your development of robust immunoassays with validated antibody pairs, optimized monoclonal antibodies, and bulk ancillary reagents. For rare target raw-material sourcing or customized solutions for muscle disease and caveolin-3 research, CamelBio is your trusted B2B partner.