Anti-CAMSAP1 Polyclonal Antibody for WB, IF/ICC, ELISA - Q5T5Y3

Core Product Specifications and Parameters

Biological Background: CAMSAP1 Function and Localization

• CAMSAP1 (Calmodulin-regulated spectrin-associated protein 1) is a key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization. Related references: PMID:19508979 PMID:21834987 PMID:24117850
• It recognizes growing microtubule minus-ends and stabilizes microtubules, protecting them from depolymerization. Unlike CAMSAP2 and CAMSAP3, CAMSAP1 tracks along the growing tips without significantly affecting polymerization rate; it dissociates after tubulin incorporation. Related references: PMID:24486153 PMID:24706919
• Through interaction with spectrin, CAMSAP1 may regulate neurite outgrowth. Related references: PMID:24117850
• Localized to the cytoplasm and cytoskeleton.
• Subject to alternative splicing and phosphorylation (phosphoprotein).
• Genetic variants are associated with intellectual disability and lissencephaly.

Experimental Guidance and Technical Tips

• The immunogen corresponds to amino acids 350-650 of human CAMSAP1; consider potential cross-reactivity with other isoforms or family members.
• For western blot (WB), a band at ~178 kDa is expected; confirm in the relevant sample system.
• Immunofluorescence (IF/ICC) can detect CAMSAP1 at the cytoskeleton; ensure proper fixation and permeabilization.
• ELISA applications may require titration of antibody concentration.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers, laboratories, and research institutes with one-stop access to IVD raw materials, technical services, and consulting. Our portfolio includes validated antibody pairs, optimized monoclonal and polyclonal antibodies like this CAMSAP1 polyclonal antibody, and bulk ancillary reagents for microtubule research. We also support rare target raw-material sourcing to accelerate your projects from concept to clinic.