Anti-CALHM2 Rabbit Polyclonal Antibody for WB and ELISA - Q9HA72

Core Product Specifications and Parameters

Biological Background: CALHM2 Function and Localization

• CALHM2 (Calcium Homeostasis Modulator Protein 2), also designated FAM26B, is a pore-forming subunit of Ca2+ homeostasis modulator channels.
• It mediates ATP release from astrocytes and ATP-induced Ca2+ influx in microglia, thereby regulating neuronal ATP and Ca2+ homeostasis, synaptic transmission, and neuroinflammatory responses.
• May form intercellular gap junctions; the exact gating mechanism remains to be fully elucidated.
• Localizes predominantly to the cell membrane as a multi-pass transmembrane protein.
• Exhibits tissue-specific expression, notably in the placenta.
• Annotated with key terms including ion channel, ion transport, transmembrane helix, and alternative splicing, underscoring its role in cellular ion homeostasis and structural diversity.

Experimental Guidance and Technical Tips

• The immunogen spans nearly the full-length protein (amino acids 1–323), which should elicit polyclonal antibodies against multiple epitopes and support applications under denaturing conditions such as Western blot and ELISA.
• For Western blot in human and rat samples, consider preparing whole-cell lysates or tissue extracts; the predicted molecular weight is approximately 36 kDa (UniProt: 36175 Da).
• Owing to the polyclonal nature, the antibody may confer high sensitivity in ELISA; validate in the relevant sample matrix to confirm specificity.
• As CALHM2 is a transmembrane protein, enrichment using membrane protein extraction protocols may improve detection.
• Cross-reactivity with rat suggests conserved epitopes; for other species, empirical verification is recommended.

CamelBio: Your One-Stop Sourcing Bridge

As a dedicated partner for the IVD industry, CamelBio provides one-stop access to raw materials including validated antibody pairs, optimized monoclonal/polyclonal antibodies, bulk ancillary reagents, and rare target sourcing such as ion channel and neuroinflammation markers. Our supply network supports manufacturers and laboratories seeking reliable anti-CALHM2 polyclonal antibodies for WB and ELISA, enabling procurement from concept to clinic with technical consultation available.