Anti-CALCRL Rabbit Polyclonal Antibody for WB, ELISA - Q16602

Core Product Specifications and Parameters

Biological Background: CALCRL Function and Localization

• CALCRL (calcitonin receptor-like receptor) is a G protein-coupled receptor whose ligand specificity is determined by heterodimerization with receptor-activity-modifying proteins (RAMPs).
  Related references: PMID:32296767, PMID:33602864, PMID:8626685
• When associated with RAMP1, the complex forms the functional CGRP (calcitonin gene-related peptide) receptor.
  Related references: PMID:33602864
• In combination with RAMP2 or RAMP3, it acts as the receptor for adrenomedullin (ADM and ADM2).
  Related references: PMID:32296767, PMID:9620797
• Ligand binding triggers G protein-mediated signaling and activation of the cAMP-dependent pathway.
  Related references: PMID:32296767, PMID:8626685
• Subcellular localization is primarily at the cell membrane.
• Predominantly expressed in lung and heart tissues.
• The protein contains key structural features including disulfide bonds, glycosylation sites, and phosphorylation sites.
• Associated with disease variants such as LMPHM8.

Experimental Guidance and Technical Tips

• The immunogen is a synthetic peptide corresponding to the C‑terminal intracellular region (aa 346‑445); the antibody may recognize both native and denatured forms.
• In WB, a band around 53 kDa is expected; validate with appropriate positive controls, such as heart or lung tissue lysates.
• For ELISA, the antibody can be used for detection; optimal coating and blocking conditions should be determined experimentally.
• Cross‑reactivity with mouse and rat proteins has been indicated; verify performance in your species of interest.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio serves as a integrated supplier of IVD raw materials, offering antibodies, antigen pairs, and ancillary reagents from early R&D through scale‑up. The anti‑CALCRL polyclonal antibody facilitates research into cardiovascular and neuroendocrine signaling pathways. We also provide sourcing solutions for rare targets, helping diagnostic developers and labs accelerate their workflows.