Anti-Cadherin-17 (LI Cadherin) Rabbit Monoclonal Antibody for WB, IHC-P, IF-P, ELISA - Q12864

Core Product Specifications and Parameters

Biological Background: Cadherin-17 Function and Localization

• Cadherin-17, also known as LI-cadherin or HPT-1, is a calcium-dependent cell adhesion protein belonging to the cadherin family.
• It mediates homophilic cell-cell adhesion, contributing to the sorting of heterogeneous cell types in tissues.
• Cadherin-17 plays a role in the morphological organization of the liver and intestine, and is involved in intestinal peptide transport.
• It is a transmembrane glycoprotein with an extracellular domain containing cadherin repeats, a single transmembrane helix, and a cytoplasmic tail.
• The protein localizes to the plasma membrane (cell membrane).
• Tissue expression is restricted to the gastrointestinal tract and pancreatic duct; it is absent from kidney, lung, liver, brain, adrenal gland, and skin.
• Three-dimensional structural data is available for cadherin-17.
• Post-translational modifications include glycosylation (as indicated by the Glycoprotein keyword).

Experimental Guidance and Technical Tips

• The immunogen is a synthetic peptide from the N-terminus (aa 1-100); consider using a peptide blocking assay to confirm specificity.
• For IHC-P, antigen retrieval conditions and antibody dilution should be optimized, especially for gastrointestinal tissue sections.
• In WB, expect a band at approximately 92 kDa; include appropriate molecular weight markers.
• Validate the antibody in relevant species (human, mouse, rat) and in cell lines or tissues expressing cadherin-17, such as intestinal or pancreatic samples.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio offers a comprehensive portfolio of IVD raw materials, including validated antibody pairs, optimized monoclonal and polyclonal antibodies, and bulk ancillary reagents. For cadherin-17-related research, we provide tailored support for rare target sourcing and supply chain management, bridging the gap from concept to clinical application. Partner with CamelBio to streamline your diagnostic development with reliable, high-quality raw materials.