Anti-CACNB3 Polyclonal Antibody for WB, ELISA - P54284

Core Product Specifications and Parameters

Biological Background: CACNB3 Function and Localization

• Voltage-dependent L-type calcium channel subunit beta-3 (CACNB3), encoded by the CACNB3 gene, is a regulatory subunit of voltage-gated calcium channels.
• Increases peak calcium current and shifts voltage dependencies of channel activation and inactivation for CACNA1B and CACNA1C channels (PubMed:8119293). Related references: PMID:8119293
• Member of the beta subunit family of voltage-gated calcium channels, which includes four genes (beta-1 to beta-4).
• Multiple isoforms produced by alternative splicing.
• Primarily localizes to the cytoplasm.
• Expressed mostly in brain, colon, and ovary.
• Phosphoprotein containing an SH3 domain; involved in calcium transport and ion channel regulation.

Experimental Guidance and Technical Tips

• The immunogen spans amino acids 355–484, likely a C-terminal region; consider its suitability for detecting full-length and truncated CACNB3 forms.
• Validated for WB and ELISA; for WB, expect a band around 55 kDa. Optimize antibody dilution and blocking conditions for your specific sample system.
• Predicted to cross-react with mouse and rat based on sequence homology; validate performance in the relevant species’ tissues or lysates.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers, labs, and research institutes with one-stop access to IVD raw materials, technical services, and consulting—covering every stage from concept to clinic. This anti-CACNB3 polyclonal antibody supports neuroscience and cardiovascular research by targeting a key calcium channel regulatory subunit. Beyond this product, CamelBio offers validated antibody pairs, optimized monoclonal/polyclonal antibodies, bulk ancillary reagents, and rare target raw-material sourcing to streamline your diagnostic development.