Anti-CAB39L Rabbit Polyclonal Antibody for WB, ELISA - Q9H9S4

Core Product Specifications and Parameters

Biological Background: CAB39L Function and Localization

• CAB39L (Calcium-binding protein 39-like), also known as MO25beta, MO2L, and antigen MLAA-34, is a 39 kDa protein encoded by the CAB39L gene in humans.
• It is a component of the STK11/LKB1 activator complex, functioning as a scaffold that binds and stabilizes the interaction between MO25 (CAB39 or CAB39L) and the STK11/LKB1 kinase.
• By similarity, CAB39L is required for the activation of STK11/LKB1, a master kinase that regulates cellular energy homeostasis, cell polarity, and growth.
• The protein belongs to the MO25/CAB39 family of calcium-binding adaptors that share a conserved role in signaling cascades.
• UniProt keywords indicate the protein is of reference proteome quality, with a resolved 3D structure and has been identified in proteomics studies.

Experimental Guidance and Technical Tips

• The immunogen used is a recombinant protein spanning the full-length human CAB39L (aa 1–337), which is expected to elicit polyclonal antibodies recognizing multiple epitopes, suitable for both denaturing (WB) and native/conformation-dependent (ELISA) applications.
• For WB, a band at approximately 39 kDa is expected; consider including both human and mouse positive control lysates to confirm species cross-reactivity.
• Given the role of CAB39L in STK11/LKB1 signaling, experimental systems with modulated LKB1 activity (e.g., cancer cell lines) may provide relevant positive controls.
• Validate antibody specificity in your target application and sample type; for immunohistochemistry or immunoprecipitation, additional verification is recommended as these are not listed in validated applications.
• Store at -20°C upon receipt; avoid multiple freeze-thaw cycles to maintain activity.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio serves as a strategic one-stop sourcing bridge for IVD manufacturers and research institutes, providing access to high-quality antibodies like this anti-CAB39L polyclonal for STK11/LKB1 signaling studies. We supply validated antibody pairs, optimized monoclonal/polyclonal antibodies, and bulk ancillary reagents to accelerate assay development. For rare or custom targets in cell signaling pathways, our team can source and qualify raw materials tailored to your diagnostic or research needs.