Anti-CAB39 Rabbit Polyclonal Antibody for WB, IF/ICC, ELISA - Q9Y376

Core Product Specifications and Parameters

Biological Background: CAB39 Function and Localization

• CAB39 (Calcium-binding protein 39), also known as MO25alpha and Protein Mo25, is a key regulatory subunit of the STK11/LKB1 kinase complex.
• It functions by stabilizing the interaction between the scaffold protein MO25 (CAB39 or CAB39L/MO25beta) and the serine/threonine kinase STK11/LKB1.
• This interaction is essential for the activation of STK11/LKB1, a master kinase that regulates cell polarity, metabolism, and growth.
• CAB39 is predominantly localized in the cytoplasm, where it carries out its scaffolding role.
• The protein has a calculated molecular weight of approximately 39.9 kDa and migrates around 40 kDa in SDS-PAGE.
• It has a solved 3D structure (as indicated by UniProt keyword) and has been identified in multiple high-throughput proteomic studies.

Experimental Guidance and Technical Tips

• The immunogen corresponds to a synthetic peptide spanning nearly the full-length human CAB39 protein (amino acids 1–341). This broad epitope coverage may contribute to the antibody's cross-reactivity with mouse and rat orthologs.
• For Western blotting (WB), expect a specific band at ~40 kDa. Optimize blocking conditions and primary antibody dilution to reduce non-specific binding.
• In immunofluorescence/immunocytochemistry (IF/ICC), validate fixation and permeabilization protocols in your cell system to preserve cytoplasmic CAB39 localization.
• For ELISA applications, consider pairing this antibody with a compatible detection antibody after appropriate validation in your assay format.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio offers a comprehensive range of IVD raw materials, including this anti-CAB39 polyclonal antibody, ideal for research and assay development focused on the STK11/LKB1 signaling pathway. With our streamlined sourcing and supply capabilities, we provide validated antibodies, optimized antibody pairs, and ancillary reagents to support diagnostic manufacturers from concept to clinic. Let CamelBio be your partner in navigating the IVD raw material landscape for rare and routine targets.