Anti-C17orf70 Rabbit Polyclonal Antibody for WB and ELISA - Q0VG06

Core Product Specifications and Parameters

Biological Background: FAAP100 Function and Localization

• FAAP100 (Fanconi anemia core complex-associated protein 100), also known as C17orf70, is a component of the Fanconi anemia (FA) core complex.
• It plays a critical role in the FA DNA damage response network by regulating FANCD2 monoubiquitination.
• FAAP100 maintains the stability of the FA core complex and is essential for cellular resistance to DNA cross-linking agents; its repression induces chromosomal instability.
• The protein is localized to the nucleus, where it participates in DNA repair and DNA-binding activities.
• Post-translational modifications include phosphorylation, and alternative splicing produces multiple isoforms.
• Keywords associated with FAAP100 include: 3D-structure, Alternative splicing, DNA damage, DNA repair, DNA-binding, Fanconi anemia, Nucleus, Phosphoprotein, Proteomics identification, Reference proteome.

Experimental Guidance and Technical Tips

• The immunogen corresponds to the C-terminal region (aa 652-881); consider validating isoform specificity as alternative splicing may generate variants.
• In Western blot, a band around 93–100 kDa is expected; additional bands could represent phosphorylation states or degradation products.
• Cross-reactivity with mouse and rat indicates epitope conservation; it is advisable to verify reactivity in your specific sample matrix.
• For ELISA, the antibody may be used with the recombinant protein immunogen as coating antigen; optimal working dilutions must be determined empirically.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers and research labs with a comprehensive sourcing solution for IVD raw materials. This anti-FAAP100 antibody supports studies in DNA damage repair and genetic stability. We also offer customized procurement of validated antibody pairs, bulk ancillary reagents, and rare-target raw materials to accelerate your assay development.