Anti-BMPR1A Rabbit Polyclonal Antibody for WB, ELISA - P36894

Core Product Specifications and Parameters

Biological Background: BMPR1A Function and Localization

• BMPR1A encodes the bone morphogenetic protein receptor type-1A, a single-pass transmembrane serine/threonine kinase also designated ALK-3, SKR5, and CD292.
• Upon ligand binding, BMPR1A assembles into a heterotetrameric complex with type II receptors, which phosphorylate and activate the type I receptor; activated BMPR1A then phosphorylates SMAD transcriptional regulators to modulate target gene expression.
• It serves as the primary receptor for BMP2, BMP4, GDF5, and GDF6 ligands, and positively regulates chondrocyte differentiation through GDF5 signaling and promotes adipogenesis in response to GDF6.
• BMPR1A may also upregulate HAMP expression, likely through its interaction with BMP2 (by similarity).
• The receptor localizes to the cell membrane and cell surface, consistent with its role as an extracellular ligand-sensing kinase.
• BMPR1A contains an ATP-binding kinase domain, disulfide bonds, glycosylation sites, and ubiquitination motifs, and is classified under several key functional keywords including serine/threonine-protein kinase, receptor, and transmembrane signaling.
• It is highly expressed in skeletal muscle, indicating a prominent role in muscle homeostasis or development.

Experimental Guidance and Technical Tips

• When using this polyclonal antibody in Western blot, a band near 60 kDa is expected; consider optimizing lysis and denaturing conditions to ensure full epitope exposure.
• For ELISA applications, pairing with a suitable detection antibody may enhance sensitivity; validate pairings in the relevant sample matrix.
• Cross-reactivity with mouse and rat BMPR1A has been noted; however, sequence alignment and experimental validation in the species of interest is recommended to confirm specificity.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio offers comprehensive access to IVD raw materials, technical services, and consulting, supporting diagnostic developers from concept to clinic. This anti-BMPR1A polyclonal antibody is part of our extensive portfolio of validated antibody pairs, optimized monoclonal/polyclonal antibodies, and bulk ancillary reagents for bone morphogenetic protein research. Our dedicated sourcing team can also assist in procuring rare-target raw materials and customized solutions to accelerate your assay development.