Anti-BMP15 Rabbit Monoclonal Antibody for WB, ELISA - O95972

Core Product Specifications and Parameters

Biological Background: BMP15 Function and Localization

• BMP15 (bone morphogenetic protein 15), also known as growth/differentiation factor 9B (GDF-9B), is a member of the transforming growth factor-beta (TGF-beta) superfamily.
• It functions as an oocyte-specific growth/differentiation factor critical for follicular development and granulosa cell growth.
• As a secreted cytokine, BMP15 contains characteristic features including a signal peptide, conserved cysteine residues forming disulfide bonds, and is processed to yield a mature bioactive protein.
• Post-translational modifications include glycosylation and phosphorylation, and the N-terminal glutamine can cyclize to pyrrolidone carboxylic acid.
• Genetic variants in BMP15 are associated with premature ovarian failure, highlighting its essential role in female fertility.
• The protein is synthesized as a precursor and cleaved to generate the active dimeric growth factor, which signals through specific receptor complexes.

Experimental Guidance and Technical Tips

• For Western blotting, consider using reduced samples from human, mouse, or rat ovarian tissue due to the predicted molecular weight of 45 kDa.
• The immunogen corresponds to amino acids 293–392 near the C‑terminus; the antibody may detect both precursor and cleaved mature forms—validate in your specific experimental context.
• In ELISA applications, this rabbit monoclonal antibody can be employed as a capture or detection reagent depending on the assay format, with cross‑reactivity to mouse and rat enabling translational research.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers, laboratories, and research institutes with a one-stop platform for IVD raw materials, technical services, and consulting—covering every stage from concept to clinic. This BMP15 rabbit monoclonal antibody exemplifies our growing portfolio of reproductive biology and fertility research reagents. We offer validated antibody pairs, optimized monoclonal/polyclonal antibodies, bulk ancillary reagents, and rare-target raw-material sourcing to accelerate your assay development and manufacturing.