Anti-BLOC1S6 Rabbit Polyclonal Antibody for WB and ELISA - Q9UL45

Core Product Specifications and Parameters

Biological Background: BLOC1S6 Function and Localization

• BLOC1S6, also known as pallidin, is a subunit of the biogenesis of lysosome-related organelles complex 1 (BLOC-1). Multiple isoforms exist due to alternative splicing.
• It is a component of the BLOC-1 complex, which is essential for the normal biogenesis of lysosome-related organelles (LROs), including platelet dense granules and melanosomes. The complex works in concert with the AP-3 complex to target membrane protein cargos into vesicles for delivery into neurites and nerve terminals.
• BLOC1S6, in association with SNARE proteins, is also involved in neurite extension and may play a broader role in intracellular vesicle trafficking, particularly in vesicle docking and fusion processes.
• The protein localizes to the cytoplasm and membrane.
• BLOC1S6 is widely expressed across tissues.
• Post-translational phosphorylation has been identified (Phosphoprotein keyword), suggesting regulatory modifications.
• Mutations in the BLOC1S6 gene are associated with Hermansky-Pudlak syndrome type 9 (HPS9), a disorder characterized by albinism and platelet storage pool deficiency.

Experimental Guidance and Technical Tips

• The immunogen encompasses the N-terminal region (amino acids 1–170) of human BLOC1S6. This region may detect full-length and some truncated isoforms; consider sequence alignment to verify cross-reactivity with specific isoforms in your experimental system.
• For Western blotting, a band of approximately 20 kDa is expected. Validated detection in human, mouse, and rat samples is indicated, but individual experimental conditions (e.g., sample preparation, antibody dilution) should be optimized.
• For ELISA applications, consider using recombinant BLOC1S6 protein as a positive control to confirm reactivity.
• As with any polyclonal antibody, lot-to-lot variability is possible; include appropriate positive and negative controls in each assay.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio offers diagnostic manufacturers and research laboratories a centralized sourcing solution for high-quality IVD raw materials. For studies on intracellular trafficking or lysosome-related organelle biogenesis, we provide validated antibody pairs, bulk ancillary reagents, and rare target sourcing options to support your assay development. Contact us to explore how our supply capabilities can streamline your next project.