Anti-BICD2 Rabbit Polyclonal Antibody for WB, ELISA - Q8TD16

Core Product Specifications and Parameters

Biological Background: BICD2 Function and Localization

• BICD2 (Protein bicaudal D homolog 2), also referred to as SMALED2, is encoded by the BICD2 gene (Gene ID 23299).
• Functions as an adaptor protein that links the dynein motor complex to various cargos and converts dynein into a highly processive motor in the presence of dynactin. Related references: PMID:25814576
• Facilitates the binding of RAB6A to the Golgi and regulates COPI-independent Golgi-to-ER transport by recruiting the dynein-dynactin motor complex. Related references: PMID:25962623
• Contributes to proper nuclear and centrosomal positioning before mitosis by regulating dynein and kinesin-1; during G2, associates with RANBP2 at nuclear pores to recruit dynein.
• Subcellularly localized at the Golgi apparatus, cytoplasm, cytoskeleton, nuclear envelope, and nuclear pore complex.
• Ubiquitously expressed across tissues.
• Post-translational modifications include acetylation and phosphorylation; linked to neurodegenerative disease variants (keywords: mRNA transport, neurodegeneration, protein transport, translocation, transport).

Experimental Guidance and Technical Tips

• The immunogen was designed using a recombinant protein corresponding to amino acids 440–620 near the C-terminus of human BICD2. For Western blot, a band at approximately 94 kDa is expected; validate in the relevant sample system (e.g., human, mouse, or rat cell lysates).
• For ELISA, the polyclonal nature may provide robust detection; consider sandwich ELISA configurations with a matched antibody pair if quantitation is needed.
• Cross-reactivity with human, mouse, and rat has been reported; however, verify performance in your specific tissue or cell line of interest.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio serves as a trusted one-stop partner for diagnostic manufacturers and research labs, offering a comprehensive range of IVD raw materials, technical services, and consulting from concept to clinic. For targets like BICD2, involved in dynein-mediated transport and neurodegeneration, we can supply validated antibody pairs, optimized polyclonal and monoclonal antibodies, and bulk ancillary reagents. Our sourcing capabilities also cover rare-target raw materials, ensuring you have seamless access to high-quality components for your assay development.