Anti-beta-Defensin 26 (Defb26) Rabbit Polyclonal Antibody for IF/ICC, ELISA - Q32ZG6

Core Product Specifications and Parameters

Biological Background: Defb26 (Beta-defensin 26) Function and Localization

• Defb26 is a member of the beta-defensin family, a group of small cationic antimicrobial peptides that play a key role in innate immunity.
• The protein exhibits antibacterial activity, contributing to host defense against microbial pathogens.
• As a secreted protein, Defb26 is released extracellularly, where it can directly interact with microbes and host cells.
• The protein contains a signal peptide (cleaved during secretion) and is predicted to form disulfide bonds characteristic of defensins.
• Defb26 is classified under Keywords: Antibiotic, Antimicrobial, Defensin, Disulfide bond, Secreted, Signal.
• The rat Defb26 (gene ID 641629) shows cross-reactivity with human DEFB126 (gene ID 81623), indicating conserved epitopes for detection.

Experimental Guidance and Technical Tips

• The immunogen corresponds to amino acids 22-128 of rat Defb26, which excludes the signal peptide; this design may enhance specific detection of the mature secreted form.
• For immunofluorescence/immunocytochemistry (IF/ICC), consider using fixation and permeabilization methods compatible with secreted proteins, and include appropriate controls.
• In ELISA applications, validate coating conditions and antibody dilutions empirically, as assay parameters can influence performance.
• As with any polyclonal antibody, lot-to-lot variability may exist; pilot experiments are recommended when switching reagent batches.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides a one-stop sourcing solution for IVD raw materials, serving diagnostic manufacturers and research labs with validated antibodies and ancillary reagents. For antimicrobial peptide research, we offer bulk quantities of this Defb26 polyclonal antibody and can assist with sourcing rare-target immunoreagents, validated antibody pairs, and optimized monoclonal antibodies to support your assay development pipeline.