Anti-ATRIP Rabbit Polyclonal Antibody - Q8WXE1

Core Product Specifications and Parameters

Biological Background: ATRIP Function and Localization

• ATRIP (ATR-interacting protein), also known as ATM and Rad3-related-interacting protein, is encoded by the ATRIP gene and undergoes alternative splicing.
• Essential for DNA damage checkpoint signaling, it is required for ATR expression, likely by stabilizing the ATR protein.
• Functions in the nucleus, where it participates in DNA damage response and repair pathways.
• Ubiquitously expressed across human tissues.
• Contains a coiled coil domain and is subject to phosphorylation; identified as a phosphoprotein.
• Classified under keywords including DNA damage, DNA repair, nucleus, and phosphoprotein.

Experimental Guidance and Technical Tips

• For Western blotting, expect a band near 86kDa in human samples; optimize gel percentage accordingly.
• In immunofluorescence/immunocytochemistry, verify nuclear localization consistent with ATRIP's function.
• For immunoprecipitation, use protein A or G beads to capture the rabbit antibody, and confirm specificity with appropriate controls.
• When using ELISA, standard protocols apply; consider validating the antibody in your sample matrix to ensure performance.
• The immunogen spans amino acids 1-260, so the polyclonal antibody may recognize multiple isoforms arising from alternative splicing.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers and research labs with one-stop access to IVD raw materials, including validated antibody pairs and optimized polyclonal antibodies like this Anti-ATRIP antibody. As your sourcing partner for DNA damage and cell cycle targets, we supply bulk ancillary reagents and support rare target raw-material procurement, accelerating assay development from concept to clinic.