Anti-ASGR2 Polyclonal Antibody for WB, ELISA - P07307

Core Product Specifications and Parameters

Biological Background: ASGR2 Function and Localization

• ASGR2 (Asialoglycoprotein receptor 2) is a C-type lectin receptor (also known as CLEC4H2) that mediates endocytosis of desialylated glycoproteins.
• It specifically recognizes terminal galactose and N-acetylgalactosamine residues on glycoproteins, facilitating their clearance from circulation.
• Ligand binding triggers receptor internalization and transport to sorting endosomes, where ligand dissociation occurs, followed by receptor recycling to the plasma membrane.
• The receptor is a transmembrane protein located on the cell surface membrane.
• Expression is highly tissue-specific, found exclusively in hepatic parenchymal cells.
• The protein undergoes post-translational modifications including phosphorylation and palmitoylation, and contains disulfide bonds.
• Alternative splicing generates multiple isoforms.
• It is involved in host-virus interactions and may function in lipoprotein metabolism.

Experimental Guidance and Technical Tips

• The immunogen spans amino acids 131–287 within the extracellular domain; consider this when designing detection or competitive binding assays.
• For Western blot, the expected molecular weight is approximately 35 kDa; validate in human hepatocyte-derived samples.
• Cross-reactivity with mouse and rat is reported; verify performance in species-matched tissue lysates.
• For ELISA, optimize coating and detection conditions suitable for polyclonal antibodies.
• As ASGR2 is liver-specific, use appropriate positive controls such as hepatic cell lines or tissue extracts.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio is a specialized IVD raw-material partner offering comprehensive sourcing, technical services, and consulting to accelerate your assay development. This Anti-ASGR2 antibody supports hepatic endocytosis and liver receptor studies, and we can supply validated antibody pairs, optimized monoclonals, bulk ancillary reagents, and rare target raw materials to meet your specific needs. Streamline your path from concept to clinic with our integrated support.