Anti-ASCC2 Polyclonal Antibody for WB, ELISA - Q9H1I8

Core Product Specifications and Parameters

Biological Background: ASCC2 Function and Localization

• ASCC2 is a component of the ASCC complex that enhances NF-kappa-B, SRF and AP1 transactivation (PubMed:12077347). Related references: PMID:12077347
• It plays a role in DNA damage repair by recruiting ASCC3 and ALKBH3 to DNA damage sites via binding to polyubiquitinated proteins with Lys-63-linked chains (PubMed:29144457). Related references: PMID:29144457
• ASCC2 is involved in the ribosome quality control (RQC) pathway, recognizing RPS20/uS10 ubiquitinated by ZNF598 and promoting recruitment of the RQT complex to stalled ribosomes (PubMed:32099016, PubMed:32579943, PubMed:36302773). Related references: PMID:32099016 PMID:32579943 PMID:36302773
• The protein is localized to the nucleus and nuclear speckles.
• ASCC2 is ubiquitously expressed across tissues.
• Post-translational modifications include phosphorylation, and the gene undergoes alternative splicing, as indicated by UniProt keywords.

Experimental Guidance and Technical Tips

• The immunogen spans the C-terminal region (amino acids 488-757) of human ASCC2, which may contribute to cross-reactivity with mouse and rat.
• For Western blotting, expect a band at approximately 86 kDa; validate in your sample system.
• ELISA can be used to assess antibody binding to the target protein.
• As a polyclonal antibody, consider lot-to-lot variability and include appropriate controls.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio serves as a comprehensive supply partner for IVD raw materials, supporting research and diagnostic development in DNA repair, ribosome quality control, and transcription regulation. For ASCC2-related studies, we offer validated polyclonal antibodies like this product, along with custom antibody development and bulk reagent sourcing. Our integrated services streamline access to critical reagents from concept to clinical application.