Anti-APLP2 Rabbit Polyclonal Antibody for WB, IF/ICC, ELISA - Q06481

Core Product Specifications and Parameters

Biological Background: APLP2 Function and Localization

• APLP2, also known as amyloid beta precursor like protein 2, is a member of the amyloid precursor protein (APP) family.
• It localizes to the cell membrane and nucleus.
• APLP2 may play a role in hemostasis regulation; its soluble form may inhibit coagulation factors.
• It inhibits serine proteases including trypsin, chymotrypsin, plasmin, factor XIa, and kallikrein.
• APLP2 modulates Cu/Zn nitric oxide-catalyzed autodegradation of GPC1 heparan sulfate side chains in fibroblasts.
• The protein is expressed in placenta, brain, heart, lung, liver, kidney, and endothelial tissues.
• Keywords highlight that it is a glycoprotein, phosphoprotein, proteoglycan, and binds copper and DNA.

Experimental Guidance and Technical Tips

• The immunogen corresponds to amino acids 370-580, an internal region of APLP2; the antibody likely recognizes full-length and possibly some isoforms.
• For western blotting, the predicted molecular weight is ~87 kDa; use appropriate molecular weight markers and loading controls.
• For immunofluorescence, expect membrane and nuclear staining patterns.
• This antibody cross-reacts with mouse and rat, but endogenous expression levels may vary; validate in the relevant sample system.
• For ELISA, consider using the recombinant protein as a positive control.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio offers validated antibodies and raw materials for IVD development, including this APLP2 rabbit polyclonal antibody. We support amyloid biology and hemostasis research with a full range of ancillary reagents and bulk supply. For customized sourcing or technical consultation, we are your one-stop partner.