Anti-APCS Rabbit Polyclonal Antibody for WB, IHC-P, ELISA - P02743

Core Product Specifications and Parameters

Biological Background: APCS Function and Localization

• APCS encodes serum amyloid P-component (SAP), also known as 9.5S alpha-1-glycoprotein, a secreted glycoprotein of the pentraxin family.
• SAP functions in innate immunity by binding to DNA and histones, potentially scavenging nuclear material from damaged cells.
• It also acts as a calcium-dependent lectin, suggesting roles in pattern recognition and opsonization.
• The protein is secreted and found in serum and urine, consistent with its systemic clearance function.
• SAP contains disulfide bonds and is N-glycosylated, features common to pentraxins.
• It is associated with amyloid deposits and is a marker for systemic amyloidosis; it also binds metal ions like calcium.

Experimental Guidance and Technical Tips

• The immunogen corresponds to the full-length human APCS sequence (aa 1–223), which may provide broad epitope coverage for polyclonal detection.
• For Western blotting, the predicted protein weight is 25 kDa; consider using appropriate gel percentages and loading controls for clear resolution.
• In IHC-P, standard antigen retrieval protocols (e.g., citrate buffer, heat-induced) may be tested; validate staining specificity with appropriate tissue controls.
• ELISA applications may benefit from checkerboard titrations to determine optimal coating antigen and antibody dilutions.
• Cross-reactivity with mouse and rat is indicated; verify in your target species by running parallel control samples.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio offers diagnostic manufacturers and research labs streamlined access to this anti-APCS antibody alongside a full portfolio of IVD raw materials. As a one-stop partner, we support your projects from concept to clinic with validated antibody pairs, bulk ancillary reagents, and tailored sourcing for rare targets. Whether you are developing assays for amyloidosis or innate immunity biomarkers, our supply network helps accelerate your workflow.