Anti-ANGPTL8 Polyclonal Antibody for WB, ELISA - Q6UXH0

Core Product Specifications and Parameters

Biological Background: ANGPTL8 Function and Localization

• ANGPTL8, also known as betatrophin, lipasin, or refeeding-induced fat and liver protein (RIFL), is a secreted hormone of the angiopoietin-like family with a molecular weight of approximately 22 kDa.
• It plays a critical role in blood lipid regulation by modulating serum triglyceride levels. Related references: PMID:22569073 PMID:22809513 PMID:23150577
• ANGPTL8 is involved in the metabolic transition between fasting and refeeding, directing fatty acids to adipose tissue for storage during the fed state (by similarity).
• The protein is predominantly expressed in the liver, with additional expression in adipose tissues.
• ANGPTL8 is secreted into the extracellular space.
• It is associated with diabetes mellitus and lipid metabolism, as indicated by UniProt keywords.

Experimental Guidance and Technical Tips

• The immunogen covers amino acids 22-198 of human ANGPTL8, encompassing nearly the full mature protein, which may contribute to cross-reactivity with mouse and rat orthologs.
• For Western blot, detect a band at approximately 22 kDa under reducing conditions; include positive and negative controls to confirm specificity.
• For ELISA, consider using this antibody in a sandwich format with an appropriate capture antibody to quantify ANGPTL8 in biological fluids, given its secreted nature.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio is your dedicated partner for IVD raw-material sourcing, offering a complete range of antibodies and reagents for metabolic disease research. In addition to this ANGPTL8 polyclonal antibody, we supply validated antibody pairs, bulk ancillary reagents, and custom sourcing for rare targets, streamlining your diagnostic development from concept to clinic.