Anti-AMHR2 Rabbit Monoclonal Antibody for WB, ELISA - Q16671

Core Product Specifications and Parameters

Biological Background: AMHR2 Function and Localization

• AMHR2 encodes the anti-Muellerian hormone type-2 receptor (also known as MIS type II receptor, MISRII, MRII), a single-pass type I membrane protein with serine/threonine kinase activity.
• Upon ligand binding (AMH/MIS), it forms a heteromeric complex with type I receptors, triggering phosphorylation cascades that activate SMAD transcriptional regulators.
• This signaling mediates key processes in sex determination, Mullerian duct regression in males, and reproductive organogenesis.
• The receptor is located on the plasma membrane, consistent with its role in extracellular signal transduction.
• Post-translational modifications include glycosylation and disulfide bond formation, which are important for receptor stability and function.
• Alternative splicing produces multiple isoforms, potentially affecting ligand binding or signaling.
• Pathogenic variants in AMHR2 cause persistent Mullerian duct syndrome (PMDS), a disorder of sexual development characterized by the presence of Mullerian derivatives in males.

Experimental Guidance and Technical Tips

• The immunogen corresponds to the N-terminal extracellular domain (aa 18-144), likely accessible for antibody binding in native conditions; consider this for applications requiring native protein recognition.
• For western blot (WB) detection, the predicted molecular weight is 63 kDa; validate the band size in relevant cell lines or tissues expressing AMHR2.
• Optimize ELISA conditions by titrating the antibody against recombinant AMHR2 extracellular domain or positive control lysates.
• Since cross-reactivity is reported for human only, validation may be required for use in other species.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers, labs, and research institutes with one-stop access to IVD raw materials, technical services, and consulting—covering every stage from concept to clinic. Our AMHR2 rabbit monoclonal antibody supports reproductive biology and TGF-beta signaling research. We offer validated antibody pairs, optimized monoclonal/polyclonal antibodies, bulk ancillary reagents, and rare target raw-material sourcing to streamline your diagnostic development.