Anti-ALDH2 Rabbit Monoclonal Antibody for WB, ELISA - P05091

Core Product Specifications and Parameters

Biological Background: ALDH2 Function and Localization

• ALDH2 encodes aldehyde dehydrogenase, mitochondrial, a key enzyme in the ALDH family responsible for oxidizing various aldehydes.
• It is critical for the detoxification of formaldehyde, a cytotoxic and carcinogenic metabolite that causes DNA crosslinks and strand breaks.
• The protein utilizes NAD+ as a cofactor and is highly expressed in mitochondria-rich tissues such as liver and heart.
• ALDH2 localizes to the mitochondrial matrix, where it performs aldehyde clearance.
• Alternative splicing produces multiple transcript variants; post-translational modifications include acetylation and ubiquitination (based on keywords).
• Genetic variants in ALDH2 are linked to alcohol-related diseases, and mutations may cause dwarfism and intellectual disability (UniProt Keywords).
• The antibody was raised against a peptide within residues 100–200 of the human protein (P05091).

Experimental Guidance and Technical Tips

• For Western blot, a band of approximately 56 kDa is expected under standard reducing conditions; we recommend using mitochondrial-enriched lysates for optimal detection.
• The antibody is validated for WB and ELISA; other applications like IHC or IF may require individual optimization and validation in the relevant sample system.
• Because the immunogen is a synthetic peptide spanning residues 100–200, the epitope may be masked in some native conformations; consider denaturing conditions for antigen retrieval if needed.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio partners with diagnostic manufacturers and laboratories to provide a comprehensive range of IVD raw materials, from validated antibody pairs to bulk ancillary reagents. Anti-ALDH2 antibodies are essential tools for research into formaldehyde metabolism, mitochondrial dysfunction, and alcohol-related disorders. Our supply platform ensures consistent quality and technical support to accelerate your assay development from concept to clinic.