Anti-AIPL1 Polyclonal Antibody for WB, IF/ICC, ELISA - Q9NZN9

Core Product Specifications and Parameters

Biological Background: AIPL1 Function and Localization

• AIPL1 (aryl-hydrocarbon-interacting protein-like 1), also known as AIPL2, is a 44 kDa protein containing tetratricopeptide (TPR) repeat domains that mediate protein-protein interactions.
• It may play a role in protein trafficking and/or protein folding and stabilization.
• Localizes to both the cytoplasm and nucleus.
• Highly expressed in the retina, specifically within the developing photoreceptor layer and adult photoreceptors.
• Mutations in AIPL1 are associated with Leber congenital amaurosis (LCA4), a severe inherited retinal dystrophy.
• Undergoes alternative splicing, leading to multiple protein isoforms.
• Identified in proteomics studies, confirming endogenous expression in human tissues.

Experimental Guidance and Technical Tips

• The immunogen spans nearly full-length human AIPL1, which may provide broad epitope recognition; for Western blot, an ~44 kDa band is expected—consider optimizing lysate preparation from retinal or relevant cell lines.
• Given AIPL1’s cytoplasmic and nuclear localization, ensure adequate permeabilization for immunofluorescence/ICC protocols.
• Cross-reactivity with mouse indicates utility in rodent models; validate in the appropriate sample system.
• As a polyclonal antibody, monitor lot-to-lot consistency in critical assays.
• For ELISA applications, pair with a suitable capture/detection antibody and validate with recombinant protein or endogenous controls.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers, labs, and research institutes with one-stop access to IVD raw materials, technical services, and consulting—covering every stage from concept to clinic. This anti-AIPL1 polyclonal antibody is a reliable tool for ocular and rare disease research, including Leber congenital amaurosis. We offer comprehensive supply solutions including validated antibody pairs, bulk ancillary reagents, and custom rare-target raw-material sourcing to accelerate your assay development.