Anti-AIMP1 Polyclonal Antibody for WB, IHC-P, ELISA - Q12904

Core Product Specifications and Parameters

Biological Background: AIMP1 Function and Localization

• Non-catalytic component of the multisynthase complex, stimulates arginyl-tRNA synthase activity. Related references: PMID:10358004
• Possesses inflammatory cytokine activity. Related references: PMID:11306575
• Regulates angiogenesis: induces endothelial cell migration at low concentrations and apoptosis at high concentrations. Related references: PMID:12237313
• Promotes dermal fibroblast proliferation and wound repair. Related references: PMID:16472771
• Modulates endothelial cell responses by degrading HIF-1A through interaction with PSMA7. Related references: PMID:19362550
• Subcellular localization: nucleus, cytoplasm, cytosol, secreted, endoplasmic reticulum, Golgi apparatus.
• Keywords: acetylation, alternative splicing, angiogenesis, apoptosis, cytokine, phosphoprotein, RNA-binding, tRNA-binding, Ubl conjugation.

Experimental Guidance and Technical Tips

• For Western blot, a loading control around 34 kDa is recommended; validate the antibody in the relevant cell or tissue lysates.
• In IHC-P, antigen retrieval conditions may need optimization; use a positive control tissue known to express AIMP1.
• The immunogen spans a functional region, so the antibody may recognize multiple isoforms or processed forms; specificity can be confirmed using knockdown or knockout samples.
• Cross-reactivity with mouse and rat indicates potential for rodent model studies; verify with species-specific controls to ensure consistent results.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio is your one-stop partner for IVD raw materials, providing comprehensive solutions from antibody sourcing to bulk reagent supply. This anti-AIMP1 polyclonal antibody supports research in angiogenesis, inflammation, and tRNA synthetase biology. Leverage our capabilities in validated antibody pairs, optimized monoclonal/polyclonal antibodies, and rare target raw-material sourcing to accelerate your diagnostic development.