Anti-AGTR2 Rabbit Polyclonal Antibody for WB and ELISA - P50052

Core Product Specifications and Parameters

Biological Background: AGTR2 Function and Localization

• Receptor Identity: The AGTR2 gene encodes the Type-2 angiotensin II receptor, also referred to as AT2 receptor, a member of the G protein-coupled receptor (GPCR) superfamily.
• Primary Function: It serves as a high-affinity receptor for angiotensin II, a key vasoconstrictor peptide in the renin-angiotensin system, signaling primarily through non-canonical, G protein-independent pathways (PubMed:28379944, PubMed:29967536, PubMed:31899086).
  Related references: PMID:28379944, PMID:29967536, PMID:31899086
• Signaling and Anti-proliferation: Cooperating with the tumor suppressor MTUS1, AGTR2 inhibits ERK2 activation and cell proliferation, counterbalancing the growth-promoting effects of the AT1 receptor (PubMed:15123706).
  Related references: PMID:15123706
• Subcellular Localization: Predominantly localized to the cell membrane, consistent with its role as a transmembrane receptor.
• Tissue Distribution: In adult tissues, highest expression is observed in the myometrium, with moderate levels in the adrenal gland, fallopian tube, and cerebellum. During fetal development, it is abundantly expressed in kidney and intestine.
• Structural Features: Contains seven transmembrane helices, disulfide bonds, and glycosylation sites, typical of class A GPCRs, with a molecular weight of approximately 41 kDa.

Experimental Guidance and Technical Tips

• The immunogen is a synthetic peptide spanning amino acids 150–250 of human AGTR2, a region that may contribute to antibody specificity; cross-reactivity with other angiotensin receptor subtypes should be evaluated in relevant assay systems.
• For Western blotting, a band corresponding to the predicted molecular weight of 41 kDa should be observed; consider using positive control lysates from AGTR2-expressing tissues such as fetal kidney or myometrium.
• This polyclonal antibody may be suitable for ELISA applications to detect native or recombinant AGTR2 under non-denaturing conditions; optimal working dilutions must be determined experimentally.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio stands as a dedicated one-stop sourcing partner for IVD raw materials, offering this anti-AGTR2 antibody to support research into the renin-angiotensin system and GPCR signaling. With established supply lines for validated antibody pairs, bulk ancillary reagents, and custom development services, CamelBio empowers diagnostic manufacturers and laboratories to accelerate their cardiovascular and metabolic assay development. From rare target sourcing to scalable production, CamelBio bridges the gap between discovery and clinical application.