Anti-AGTR2 Rabbit Monoclonal Antibody for WB, ELISA - P50052

Core Product Specifications and Parameters

Biological Background: Type-2 angiotensin II receptor Function and Localization

• Type-2 angiotensin II receptor, also known as AT2 receptor, is encoded by the AGTR2 gene.
• Functions as a receptor for angiotensin II, mediating vasoconstriction and signaling through non-canonical G protein- and beta-arrestin independent pathways (PubMed:28379944, PubMed:29967536, PubMed:31899086). Related references: PMID:28379944, PMID:29967536, PMID:31899086
• Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation (PubMed:15123706). Related references: PMID:15123706
• Subcellular localization is predominantly at the cell membrane.
• Highly expressed in adult myometrium, with lower levels in adrenal gland and fallopian tube; also expressed in cerebellum and very highly in fetal kidney and intestine.
• Classified as a G protein-coupled receptor with transmembrane domains, disulfide bonds, glycosylation, and resolved 3-D structure.

Experimental Guidance and Technical Tips

• The immunogen peptide (aa 264-363) targets the receptor's C-terminal region; consider this for applications requiring native protein detection.
• For Western blot, the predicted molecular weight is approximately 41 kDa; validate band size in the relevant sample system.
• For ELISA, optimize coating conditions and antibody concentration; rabbit monoclonal antibodies typically offer high affinity and specificity.
• Cross-reactivity with mouse and rat indicates a conserved epitope; verify species-specific reactivity in your experimental context.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio offers a comprehensive IVD raw-material sourcing platform, supporting diagnostic manufacturers and research labs from discovery to commercialization. This AGTR2 antibody is part of our extensive cardiovascular biomarker panel, supplemented by validated antibody pairs, optimized reagents, and rare-target sourcing solutions to streamline your assay development pipeline.