Anti-ACP1 (LMW-PTP) Rabbit Polyclonal Antibody for WB and ELISA - P24666

Core Product Specifications and Parameters

Biological Background: ACP1 Function and Localization

• ACP1 encodes a low molecular weight phosphotyrosine protein phosphatase, also known as LMW-PTP, HAAP, adipocyte acid phosphatase, and red cell acid phosphatase 1.
• The enzyme dephosphorylates tyrosine-phosphorylated proteins, low-molecular-weight aryl phosphates, and natural and synthetic acyl phosphates.
• Two isoforms are produced by alternative splicing; isoform 2 lacks phosphatase activity.
• Localized predominantly in the cytoplasm.
• Highly expressed in T-lymphocytes, suggesting a role in immune cell signaling.
• Post-translational modifications include acetylation and phosphorylation, which may regulate its activity.
• Classified as a protein phosphatase (hydrolase), it plays a role in cellular signal transduction by modulating phosphotyrosine levels.

Experimental Guidance and Technical Tips

• For WB, consider a dilution range appropriate for polyclonal antibodies; validate with positive controls such as human or mouse T-cell lysates.
• For ELISA, test with recombinant protein or cell extracts to determine binding efficiency.
• The immunogen corresponds to a fragment (aa15-144) that may be conserved across isoforms; verify isoform detection if needed.
• Cross-reactivity with mouse enables use in mouse models; validate in the relevant tissue or cell line.
• Ship on ice bags; store at recommended temperatures upon receipt to maintain stability.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers and researchers with reliable access to a broad portfolio of IVD raw materials, including validated antibody pairs, optimized monoclonal and polyclonal antibodies, and bulk ancillary reagents. This ACP1 antibody supports studies on phosphoprotein phosphatase signaling and immune cell function. For your projects on phosphatase-related biomarkers or assay development, CamelBio offers one-stop sourcing and technical consultation to accelerate your transition from concept to clinic.