Anti-ACMSD Rabbit Polyclonal Antibody for WB, ELISA - Q8TDX5

Core Product Specifications and Parameters

Biological Background: ACMSD Function and Localization

• ACMSD encodes 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase, a rate-limiting enzyme in the kynurenine pathway that converts tryptophan catabolite ACMS to AMS.
  Related references: PMID:12140278

• By decarboxylating ACMS, ACMSD prevents its spontaneous cyclization to quinolinate, a potent neurotoxin and NAD precursor, thus protecting against quinolinate-mediated neuronal damage.
  Related references: PMID:12140278, PMID:19843166

• ACMSD is a zinc-dependent metalloenzyme, containing a conserved metal-binding domain essential for its decarboxylase activity.

• Alternative splicing of the ACMSD gene generates multiple transcript variants, potentially yielding isoforms with distinct regulatory or functional properties.

• The enzyme has been detected in various human tissues through proteomics identification, reflecting its broad metabolic role.

• The predicted molecular weight of the canonical ACMSD isoform (336 amino acids) is 38 kDa.

Experimental Guidance and Technical Tips

• The immunogen corresponds to full-length human ACMSD (residues 1–336), which may support detection of multiple splice isoforms; consider the possibility of additional bands in Western blots.

• For Western blot, a predominant band near 38 kDa is expected; validate in human, mouse, or rat tissue homogenates to confirm cross-reactivity and specificity.

• ELISA may be employed for antibody titer determination or ACMSD antigen quantification under empirically optimized conditions.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio serves as a one-stop sourcing partner for IVD manufacturers, providing integrated raw material supply, technical consultation, and project support from research to clinical application. This ACMSD polyclonal antibody, targeting a critical enzyme in tryptophan metabolism and neuroprotection, is backed by our ability to deliver validated antibody pairs, optimized monoclonal/polyclonal reagents, ancillary bulk materials, and custom sourcing for rare targets. We are dedicated to accelerating your diagnostic development with reliable, research-grade raw materials.