ALS2 Rabbit pAb Polyclonal Antibody for ALS2 (Alsin) with Applications in WB, IF/ICC, IF-P, ELISA - Q96Q42

Core Product Specifications and Parameters

Biological Background: ALS2 (Alsin) Function and Localization

• Alsin is a putative GTPase regulator that controls survival and growth of spinal motor neurons (By similarity).
• Mutations in the ALS2 gene are associated with amyotrophic lateral sclerosis (ALS2), a neurodegenerative disorder, as well as other motor neuron diseases.
• The protein is subject to alternative splicing and undergoes post-translational modifications, including acetylation and phosphorylation.
• ALS2 belongs to the guanine-nucleotide releasing factor family, suggesting its involvement in intracellular signaling pathways.
• The antibody's immunogen corresponds to residues 260-429, a region likely conserved across species, enabling cross-reactivity with mouse and rat.

Experimental Guidance and Technical Tips

• The immunogen is a recombinant protein fragment covering amino acids 260-429, so the antibody may recognize multiple alsin isoforms. Validate specificity in your system using appropriate controls.
• For Western blotting, the predicted molecular weight is ~184 kDa; ensure adequate gel separation and transfer conditions for large proteins.
• In immunofluorescence and immunohistochemistry, optimize fixation and permeabilization, and include positive and negative controls in relevant tissues or cell lines.
• Cross-reactivity with mouse and rat makes the antibody suitable for translational studies in rodent models of motor neuron disease.

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CamelBio provides comprehensive sourcing solutions for IVD raw materials, including validated antibodies for neurodegenerative disease targets such as ALS2. Our portfolio features polyclonal and monoclonal antibodies, recombinant proteins, and ancillary reagents, supporting diagnostic manufacturers and research laboratories from assay development to clinical application. Partner with CamelBio to streamline your supply chain with high-quality, cost-effective raw materials and expert technical support.