ALDH9A1 Rabbit pAb - P49189

Core Product Specifications and Parameters

Biological Background: ALDH9A1 Function and Localization

• ALDH9A1, also known as 4-trimethylaminobutyraldehyde dehydrogenase, is a member of the aldehyde dehydrogenase family and functions as an NAD-dependent oxidoreductase.
• It converts gamma-trimethylaminobutyraldehyde into gamma-butyrobetaine with high efficiency, and also catalyzes the oxidation of a broad range of aldehydes from biogenic amines and polyamines, though with lower efficiency.
• The enzyme localizes predominantly in the cytoplasm and cytosol.
• ALDH9A1 is detected in brain at the protein level. Related references: PMID:8645224
• ALDH9A1 exhibits high expression in adult liver, skeletal muscle, and kidney, with lower levels in heart, pancreas, lung, and brain. Related references: PMID:8786138
• Within the brain, ALDH9A1 is expressed in all regions, with highest levels in the spinal cord and lowest in the occipital pole. Related references: PMID:8786138
• The protein undergoes acetylation and alternative splicing, which may generate multiple isoforms.
• Keywords include 3D-structure, indicating experimentally determined structural data is available.

Experimental Guidance and Technical Tips

• The immunogen corresponds to the N-terminal region (amino acids 1–180) of human ALDH9A1, which may provide specificity for the target. Consider validating reactivity in the relevant sample system.
• For Western blot (WB), a band around 54 kDa is expected; optimize lysate preparation and antibody dilution.
• In immunofluorescence/immunocytochemistry (IF/ICC), appropriate fixation and permeabilization conditions should be tested to preserve antigenicity.
• For ELISA, the antibody may be suitable as a capture or detection reagent; pairing with a matched antibody is recommended.
• Cross-reactivity with human, mouse, and rat ALDH9A1 suggests the antibody can be used across these species, but verification in each species is advised.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio offers diagnostic manufacturers and research labs a comprehensive sourcing solution for IVD raw materials, from antibodies to ancillary reagents. This ALDH9A1 antibody supports aldehyde metabolism studies and is part of our portfolio of validated polyclonal antibodies optimized for multiple applications. Through our one-stop platform, we also provide custom antibody development, bulk reagent supply, and rare target sourcing to accelerate your diagnostic development.